NO EVIDENCE FOR ALLELIC ASSOCIATION BETWEEN BIPOLAR DISORDER AND MONOAMINE-OXIDASE-A GENE POLYMORPHISMS

被引：52

作者：

CRADDOCK, N

DANIELS, J

EBERTS, E

REES, M

MCGUFFIN, P

OWEN, MJ

机构：

[1] UNIV WALES COLL MED,DEPT PSYCHOL MED,CARDIFF CF4 4XN,S GLAM,WALES

[2] UNIV WALES COLL MED,DEPT MED GENET,CARDIFF,S GLAM,WALES

[3] UNIV WASHINGTON,SCH MED,DEPT PSYCHIAT,ST LOUIS,MO

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1995年 / 60卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

BIPOLAR DISORDER; MONOAMINE OXIDASE; ASSOCIATION STUDY; AFFECTIVE DISORDERS;

D O I：

10.1002/ajmg.1320600412

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have tested the hypothesis that DNA markers in the MAOA gene show allelic association with bipolar affective disorder, Eighty-four unrelated Caucasian patients with DSM III-R bipolar disorder and 84 Caucasian controls were typed for three markers in MAOA: a dinucleotide repeat in intron 2, a VNTR in intron 1, and an Fnu4HI RFLP in exon 8. No evidence for allelic association was observed between any of the markers and bipolar disorder. (C) 1995 Wiley-Liss, Inc.

引用

页码：322 / 324

页数：3

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