ANTIGEN-INDUCED CONFORMATIONAL-CHANGES IN ANTIBODIES - A PROBLEM FOR STRUCTURAL PREDICTION AND DESIGN

被引：56

作者：

STANFIELD, RL

WILSON, IA

机构：

[1] Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037

来源：

TRENDS IN BIOTECHNOLOGY | 1994年 / 12卷 / 07期

关键词：

D O I：

10.1016/0167-7799(94)90139-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent work has shown that large conformational changes in antibodies can accompany antigen binding. These structural changes can alter dramatically the size, shape and charge distribution in the antigen-binding pocket, and may present problems for accurate modeling of antibody structures.

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页码：275 / 279

页数：5

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