AUTORADIOGRAPHIC STUDY OF C-14 SULPIRIDE IN MONKEY

Substituted benzamides were the object of numerous metabolic studies including many by whole body autoradiography of rats and mice. The present study reports autoradiographic data concerning 14C-labeled sulpuride in monkey. The study was limited to the brain in order to elucidate the controversial question as to whether the drug can cross the blood-brain barrier. In monkey, as in rat and mouse, there evidently is no localization in the brain as can be clearly seen on the autoradiograms. In view of these results and of the undeniable neuroleptic properties of sulpiride, an indirect mode of action through the release of endogenous mediators is proposed.