THE PROLINE AND BETA-LACTOGLOBULIN MEDIATED ASYMMETRIC SELF-CONDENSATION OF BETA-IONYLIDENEACETALDEHYDE, RETINAL AND RELATED-COMPOUNDS

被引：23

作者：

ASATO, AE

WATANABE, C

LI, XY

LIU, RSH

机构：

[1] Department of Chemistry, University of Hawaii, Honolulu

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)79825-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Proline was found to effectively mediate the asymmetric reaction of beta-ionylideneacetaldehyde 1A, retinal and related alpha,beta-unsaturated aldehydes to form their corresponding self-condensation products in reasonable enantiomeric excess (up to 65% ee). This same interesting conversion was also observed when 1A was incubated in the presence of the milk whey protein beta-lactoglobulin (BLG).

引用

页码：3105 / 3108

页数：4

共 16 条

[1]

Buchschacher P., 1985, ORG SYNTH, V63, P37

[2]

COPPOLA GM, 1987, ASYMMETRIC SYNTHESIS, P267

[3] SYNTHESIS OF OPTICALLY-ACTIVE COMPOUNDS - A LARGE-SCALE PERSPECTIVE [J].