COMPARISON OF 4 INDEPENDENTLY DETERMINED STRUCTURES OF HUMAN RECOMBINANT INTERLEUKIN-4

被引：36

作者：

SMITH, LJ

REDFIELD, C

SMITH, RAG

DOBSON, CM

CLORE, GM

GRONENBORN, AM

WALTER, MR

NAGANBUSHAN, TL

WLODAWER, A

机构：

[1] UNIV OXFORD,NEW CHEM LAB,OXFORD OX1 3QT,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

[3] NIDDKD,CHEM PHYS LAB,BETHESDA,MD 20892

[4] UNIV ALABAMA,DEPT PHARMACOL,BIRMINGHAM,AL 35294

[5] SCHERING PLOUGH CORP,RES INST,BLOOMFIELD,NJ 07003

[6] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MACROMOLEC STRUCT LAB,FREDERICK,MD 21702

来源：

NATURE STRUCTURAL BIOLOGY | 1994年 / 1卷 / 05期

关键词：

D O I：

10.1038/nsb0594-301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four independent structures of human interleukin-4, two determined by nuclear magnetic resonance techniques and two ky X-ray diffraction, have keen compared in detail. The core of this four helix bundle protein is very similar in all the structures but there are some differences in loop regions that are known to be mobile in solution. Careful comparison of the experimental data sets and the methods of analysis of the different laboratories has provided clues to the sources of most of the differences, and also answered some general questions about the accuracy of protein structure determination by these two techniques.

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收藏

页码：301 / 310

页数：10

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