IN-VIVO EVALUATION OF IMMUNE-RESPONSES IN LEISHMANIASIS - THE USE OF CROSS-SPECIES LEISHMANIN PREPARATIONS FOR SKIN TESTING

被引:15
作者
AKUFFO, H
DARCE, M
MAASHO, K
BERHAN, TY
机构
[1] KAROLINSKA INST,HUDDINGE HOSP,DEPT INFECT DIS,HUDDINGE,SWEDEN
[2] ALL AFRICA LEPROSY & REHABIL TRAINING CTR,ADDIS ABABA,ETHIOPIA
[3] CTR NACL HIGINE & EPIDEMIOL,MANAGUA,NICARAGUA
关键词
D O I
10.4269/ajtmh.1995.53.16
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Skin test reactivity to two commercial preparations of Leishmania major leishmanin was evaluated in leishmaniasis patents from Ethiopia (L. aethiopica) and Nicaragua (probably L. braziliensis complex). The purpose of using different preparations of L. major was to evaluate whether L. major skin test antigens could generally be used to detect leishmaniasis due to L. aethiopica and L. braziliensis. One preparation was superior in identifying the majority (83-90%) of confirmed cases of local cutaneous leishmaniasis (LCL) from Ethiopia. In vitro responses to promastigotes of Leishmania spp. correlated well with leishmanin positivity to this preparation. The skin test antigen, which performed less well (showing a positive result in only 50% of the LCL patents), showed promise when used to test active and cured cases of leishmaniasis in Nicaragua (positive result in 92% of the active and cured patents). Cross-reacting Leishmania spp. may be considered for use in the preparation of standardized leishmanin antigen; however, differences in the commercial preparation or the diluent in which the parasites are prepared may affect antigenicity and thus its efficacy in detecting different forms of leishmaniasis in different geographic areas.
引用
收藏
页码:16 / 22
页数:7
相关论文
共 35 条
[1]   THE PATHOGENESIS OF LEISHMANIA-AETHIOPICA INFECTION IN BALB/C MICE [J].
AKUFFO, HO ;
WALFORD, C ;
NILSEN, R .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1990, 32 (02) :103-110
[2]  
AKUFFO HO, 1988, J IMMUNOL, V141, P2461
[3]   EVALUATION OF THE EFFICACY OF IRAN LEISHMANIN AND COMPARISON WITH LEISHMANINS FROM WELLCOME (UK) AND ROMA (ITALY) IN CURED CUTANEOUS LEISHMANIASIS PATIENTS [J].
ALIMOHAMMADIAN, MH ;
KIVANJAH, M ;
PAK, F ;
GAZNAVIA, A ;
KHARAZMI, A .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1993, 87 (05) :550-550
[4]   DELAYED-TYPE HYPERSENSITIVITY AND LYMPHOCYTE-PROLIFERATION IN RESPONSE TO LEISHMANIA-MAJOR INFECTION IN A GROUP OF CHILDREN IN JERICHO [J].
ALVARADO, R ;
ENK, C ;
JABER, K ;
SCHNUR, L ;
FRANKENBURG, S .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1989, 83 (02) :189-192
[5]  
BADERO R, 1990, T R SOC TROP MED HYG, V84, P226
[6]  
BOYUM A, 1969, SCAND J CLIN LAB I S, V25, P77
[7]   PARASITE CAUSING CUTANEOUS LEISHMANIASIS IN ETHIOPIA [J].
BRAY, RS ;
ASHFORD, RW ;
BRAY, MA .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1973, 67 (03) :345-348
[8]  
Bryceson A. D. M, 1970, P ROY SOC MED, V63, P40
[10]   MOLECULAR CHARACTERIZATION OF A KINESIN-RELATED ANTIGEN OF LEISHMANIA-CHAGASI THAT DETECTS SPECIFIC ANTIBODY IN AFRICAN AND AMERICAN VISCERAL LEISHMANIASIS [J].
BURNS, JM ;
SHREFFLER, WG ;
BENSON, DR ;
GHALIB, HW ;
BADARO, R ;
REED, SG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :775-779