RELATIONSHIP OF GLUCOCORTICOID DOSAGE TO SERUM BONE GLA-PROTEIN CONCENTRATION IN PATIENTS WITH RHEUMATOLOGIC DISORDERS

被引：50

作者：

KOTOWICZ, MA

HALL, S

HUNDER, GG

CEDEL, SL

MANN, KG

RIGGS, BL

机构：

[1] MAYO CLIN & MAYO FDN,DIV ENDOCRINOL METAB & INTERNAL MED,200 1ST ST SW,ROCHESTER,MN 55905

[2] MAYO CLIN & MAYO FDN,DIV RHEUMATOL & INTERNAL MED,ROCHESTER,MN 55905

[3] MAYO CLIN & MAYO FDN,DEPT HLTH SCI RES,ROCHESTER,MN 55905

[4] UNIV VERMONT,DEPT BIOCHEM,BURLINGTON,VT

来源：

ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 10期

关键词：

D O I：

10.1002/art.1780331005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serum bone Gla‐protein (BGP) measurements in 50 rheumatic disease patients receiving long‐term prednisone therapy revealed an inverse relationship (r = −0.71, P < 0.001) between serum BGP levels and prednisone dosage. Multiple regression analysis demonstrated significant relationships (R2 = 0.72, P < 0.001) between serum BGP1/2 and prednisone dosage, dosage2, serum creatinine, age, and an age‐creatinine interaction. This model predicts the suppression of serum BGP with low dosages of steroids and 50% suppression with dosages of 20–25 mg/day. Copyright © 1990 American College of Rheumatology

引用

页码：1487 / 1492

页数：6

共 35 条

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