ORALLY ACTIVE WATER-SOLUBLE N,O-ACYL TRANSFER PRODUCTS OF A BETA,GAMMA-BISHYDROXYL AMIDE CONTAINING RENIN INHIBITOR

被引：30

作者：

HURLEY, TR ^{[1
]}

COLSON, CE ^{[1
]}

HICKS, G ^{[1
]}

RYAN, MJ ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PHARMACEUT RES,DEPT PHARMACOL,ANN ARBOR,MI 48106

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 10期

关键词：

D O I：

10.1021/jm00062a024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1496 / 1498

页数：3

共 9 条

[1]

BERGMANN M, 1923, Z PHYSIOL CHEM, V131, P1

[2] RENIN INHIBITORS CONTAINING HYDROPHILIC GROUPS - TETRAPEPTIDES WITH ENHANCED AQUEOUS SOLUBILITY AND NANOMOLAR POTENCY [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

FREIDINGER, RM ;

RITTLE, KE ;

PAYNE, LS ;

BOGER, J ;

WHITTER, WL ;

LAMONT, BI ;

ULM, EH ;

BLAINE, EH ;

SCHORN, TW ;

VEBER, DF .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (10) :1918-1923

[3] RENIN INHIBITORS [J].

GREENLEE, WJ .

MEDICINAL RESEARCH REVIEWS, 1990, 10 (02) :173-236

[4]

KLEINERT HD, 1993, BIOPHARM-TECHNOL BUS, V6, P36

[5] KINETICS AND MECHANISM OF ISOMERIZATION OF CYCLOSPORINE-A [J].

OLIYAI, R ;

STELLA, VJ .

PHARMACEUTICAL RESEARCH, 1992, 9 (05) :617-622

[6] STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF 2-AMINO-4-THIAZOLE-CONTAINING RENIN INHIBITORS [J].

PATT, WC ;

HAMILTON, HW ;

TAYLOR, MD ;

RYAN, MJ ;

TAYLOR, DG ;

CONNOLLY, CJC ;

DOHERTY, AM ;

KLUTCHKO, SR ;

SIRCAR, I ;

STEINBAUGH, BA ;

BATLEY, BL ;

PAINCHAUD, CA ;

RAPUNDALO, ST ;

MICHNIEWICZ, BM ;

OLSON, SC .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (14) :2562-2572

[7] REARRANGEMENTS BETWEEN PRIMARY ETHANOLAMIDES OF CARBOXYLIC ACIDS AND THE CORRESPONDING AMINOETHYLESTERS [J].

PHILLIPS, AP ;

BALTZLY, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1947, 69 (02) :200-204

[8] WATER-SOLUBLE RENIN INHIBITORS - DESIGN OF A SUBNANOMOLAR INHIBITOR WITH A PROLONGED DURATION OF ACTION [J].

ROSENBERG, SH ;

WOODS, KW ;

SHAM, HL ;

KLEINERT, HD ;

MARTIN, DL ;

STEIN, H ;

COHEN, J ;

EGAN, DA ;

BOPP, B ;

MERITS, I ;

GARREN, KW ;

HOFFMAN, DJ ;

PLATTNER, JJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (07) :1962-1969

[9]

TOMASSELLI AG, 1991, CHIM OGGI, V9, P6

← 1 →