NUCLEOSIDES AND NUCLEOTIDES .126. INCORPORATION OF A MUTAGENIC NUCLEOSIDE, 5-FORMYL-2'-DEOXYURIDINE, INTO AN OLIGODEOXYRIBONUCLEOTIDE

被引：26

作者：

MATSUDA, A

INADA, M

NARA, H

OHTSUKA, E

ONO, A

机构：

[1] Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, 060, Kita-12

[2] Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, Hachioji, Tokyo

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

NUCLEOSIDE; 5-FORMYL-2'-DEOXYURIDINE; OLIGODEOXYRIBONUCLEOTIDE; MUTAGENESIS; GAMMA-IRRADIATION;

D O I：

10.1016/S0960-894X(01)80757-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An oligodeoxyribonucleotide (TT1TTT) containing 5-formyl-2'-deoxyuridine (1) has been synthesized. Protection of the formyl group of 3',5'-di-O-acetyl-5-formyl-2'-deoxyuridine (3) with N,N-di-(m-chlorophenyl)-ethylenediamine (4d) afforded the imidazolidine derivative 5d, which was converted into the nucleoside 3'-phosphoramidite 7. Incorporation of 7 into an oligonucleotide and then acid-hydrolysis gave the oligomer containing 1. The nucleoside composition was confirmed after conversion of 1 in the oligomer into 5-hydroxymethyl-2'-deoxyuridine.

引用

页码：2751 / 2754

页数：4

共 16 条

[1] BASE-CATALYZED ANOMERIZATION OF BETA-5-FORMYLURIDINE - CRYSTAL AND MOLECULAR-STRUCTURE OF ALPHA-5-FORMYLURIDINE [J].