A FACILE SYNTHESIS OF THE NOVEL NEUROKININ-A ANTAGONIST SR-48968

被引：14

作者：

HALE, JJ

FINKE, PE

MACCOSS, M

机构：

[1] Department of Medicinal Chemical Research Merck Research Laboratories, Rahway, NJ 07065-0900

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

SR; 48968; NEUROKININ-A; (2S)-(3,4-DICHLOROPHENYL)-4-PENTENOIC ACID; REDUCTIVE AMINATION;

D O I：

10.1016/S0960-894X(01)80901-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A convenient synthesis of the potent Neurokinin A antagonist SR 48968 (N-methyl-N-(4-(5-acetamido-4-phenylpiperidinyl)-(2S)-(3,4-dichlorophenyl)butyl)benzamide) is described.

引用

页码：319 / 322

页数：4

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