BIOSYNTHESIS OF THE FUNGAL POLYKETIDE, CUBENSIC ACID FROM XYLARIA-CUBENSIS

被引:29
作者
OHAGAN, D
ROGERS, SV
DUFFIN, GR
EDWARDS, RL
机构
[1] STERLING WINTHROP RES CTR,DEPT CHEM DEV,ALNWICK NE66 2JH,NORTHD,ENGLAND
[2] UNIV BRADFORD,BRADFORD BD7 1DP,W YORKSHIRE,ENGLAND
关键词
D O I
10.1016/S0040-4039(00)61152-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The biosynthetic origin of cubensic acid (1) from Xylaria cubensis is reported. Analysis of this metabolite suggests a modular polyketide assembly with an underlying biogenetic basis.
引用
收藏
页码:5585 / 5588
页数:4
相关论文
共 22 条
[1]   FUNICULOSIN, A NEW ANTIBIOTIC .2. STRUCTURE ELUCIDATION AND ANTIFUNGAL ACTIVITY [J].
ANDO, K ;
MATSUURA, I ;
NAWATA, Y ;
ENDO, H ;
SASAKI, H ;
OKYTOMI, T ;
SAEHI, T ;
TAMURA, G .
JOURNAL OF ANTIBIOTICS, 1978, 31 (06) :533-538
[2]   STUDIES IN RELATION TO BIOSYNTHESIS .14. THE ORIGIN OF THE NUCLEAR METHYL GROUPS IN MYCOPHENOLIC ACID [J].
BIRCH, AJ ;
ENGLISH, RJ ;
MASSYWESTROPP, RA ;
SLAYTOR, M ;
SMITH, H .
JOURNAL OF THE CHEMICAL SOCIETY, 1958, (JAN) :365-368
[3]  
BODO B, 1973, TETRAHEDRON LETT, P1631
[4]  
BODO B, 1974, TETRAHEDRON LETT, P1443
[5]   UNIFIED STEREOCHEMICAL MODEL OF POLYETHER ANTIBIOTIC-STRUCTURE AND BIOGENESIS [J].
CANE, DE ;
CELMER, WD ;
WESTLEY, JW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (11) :3594-3600
[6]  
CONADIO S, 1991, SCIENCE, V252, P675
[7]   AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA [J].
CORTES, J ;
HAYDOCK, SF ;
ROBERTS, GA ;
BEVITT, DJ ;
LEADLAY, PF .
NATURE, 1990, 348 (6297) :176-178
[8]   METABOLITES OF THE HIGHER FUNGI .26. CUBENSIC ACID, 3,7,11,15-TETRAHYDROXY-18-(HYDROXYMETHYL)-2,4,6,10,14,16,20-HEPTAMETHYLDOCOSA-4E,8E,12E,16E-TETRAENOIC ACID, A NOVEL POLYSUBSTITUTED C22 FATTY-ACID FROM THE FUNGUS XYLARIA-CUBENSIS (MONT) FR WITH SUBSTITUENTS AND SUBSTITUTION PATTERN SIMILAR TO THE MACROLIDE ANTIBIOTICS [J].
EDWARDS, RL ;
MAITLAND, DJ ;
WHALLEY, AJS .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (06) :1411-&
[9]  
FRIEDMAN SM, 1964, J BIOL CHEM, V239, P2384
[10]   PLANT PATHOTOXINS FROM ALTERNARIA-CITRI - THE MAJOR TOXIN SPECIFIC FOR ROUGH LEMON PLANTS [J].
GARDNER, JM ;
KONO, Y ;
TATUM, JH ;
SUZUKI, Y ;
TAKEUCHI, S .
PHYTOCHEMISTRY, 1985, 24 (12) :2861-2867