CELLULAR ENGINEERING FOR THE TREATMENT OF METABOLIC DISORDERS - PROSPECTS FOR THERAPY IN DIABETES

被引:36
作者
NEWGARD, CB [1 ]
机构
[1] UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,DALLAS,TX 75235
来源
BIO-TECHNOLOGY | 1992年 / 10卷 / 10期
关键词
D O I
10.1038/nbt1092-1112
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Significant advances in the areas of identification of disease susceptibility genes and gene transfer technologies have fueled new initiatives in cellular engineering as a means for treating metabolic disease. This article utilizes new findings from such work as the blueprint for a discussion of the prospects for gene therapy in diabetes mellitus.
引用
收藏
页码:1112 / 1120
页数:9
相关论文
共 63 条
[1]  
ALCOLADO JC, 1991, DIABETOLOGIA, V34, P234
[2]   SYSTEMIC DELIVERY OF RECOMBINANT PROTEINS BY GENETICALLY MODIFIED MYOBLASTS [J].
BARR, E ;
LEIDEN, JM .
SCIENCE, 1991, 254 (5037) :1507-1509
[3]   MOLECULAR DEFECTS IN DIABETES-MELLITUS [J].
BELL, GI .
DIABETES, 1991, 40 (04) :413-422
[4]   MOLECULAR-BIOLOGY OF MAMMALIAN GLUCOSE TRANSPORTERS [J].
BELL, GI ;
KAYANO, T ;
BUSE, JB ;
BURANT, CF ;
TAKEDA, J ;
LIN, D ;
FUKUMOTO, H ;
SEINO, S .
DIABETES CARE, 1990, 13 (03) :198-208
[5]   TRANSPLANTABLE INSULINOMA IN RAT [J].
CHICK, WL ;
WARREN, S ;
CHUTE, RN ;
LIKE, AA ;
LAURIS, V ;
KITCHEN, KC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (02) :628-632
[6]   MODULATION OF GLUCOSE-INDUCED INSULIN-SECRETION FROM A RAT CLONAL BETA-CELL LINE [J].
CLARK, SA ;
BURNHAM, BL ;
CHICK, WL .
ENDOCRINOLOGY, 1990, 127 (06) :2779-2788
[7]  
COATS WS, 1991, J BIOL CHEM, V266, P16113
[8]   SYSTEMIC DELIVERY OF HUMAN GROWTH-HORMONE BY INJECTION OF GENETICALLY ENGINEERED MYOBLASTS [J].
DHAWAN, J ;
PAN, LC ;
PAVLATH, GK ;
TRAVIS, MA ;
LANCTOT, AM ;
BLAU, HM .
SCIENCE, 1991, 254 (5037) :1509-1512
[9]   BETA-CELL LINES DERIVED FROM TRANSGENIC MICE EXPRESSING A HYBRID INSULIN GENE ONCOGENE [J].
EFRAT, S ;
LINDE, S ;
KOFOD, H ;
SPECTOR, D ;
DELANNOY, M ;
GRANT, S ;
HANAHAN, D ;
BAEKKESKOV, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :9037-9041
[10]   HETEROGENEITY OF EXPRESSION AND SECRETION OF NATIVE AND MUTANT [ASPB10]INSULIN IN ATT20 CELLS [J].
FERBER, S ;
GROSS, DJ ;
VILLAKOMAROFF, L ;
DANEHY, F ;
VOLLENWEIDER, F ;
MEYER, K ;
LOEKEN, MR ;
KAHN, CR ;
HALBAN, PA .
MOLECULAR ENDOCRINOLOGY, 1991, 5 (03) :319-326