MAPPING THE MELATONIN RECEPTOR .1. THE 5-METHOXYL GROUP OF MELATONIN IS NOT AN ESSENTIAL REQUIREMENT FOR BIOLOGICAL-ACTIVITY

被引：46

作者：

GARRATT, PJ

JONES, R

ROWE, SJ

SUGDEN, D

机构：

[1] UNIV LONDON UNIV COLL,DEPT ANAT & DEV BIOL,LONDON WC1E 6BT,ENGLAND

[2] KINGS COLL LONDON,DIV BIOMED SCI,PHYSIOL GRP,LONDON W8 7AH,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(01)80565-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of indole-derived melatonin analogues have been prepared lacking the C-5 methoxyl group. Many of these analogues are melatonin-receptor agonists and the previous assumption that the 5-OMe group was required for biological activity appears to have been an artefact mainly arising from the poor binding affinities of the small range of compounds tested.

引用

页码：1555 / 1558

页数：4

共 34 条

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