MAPPING THE MELATONIN RECEPTOR .2. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF INDOLE DERIVED MELATONIN ANALOGS WITH RESTRICTED CONFORMATIONS OF THE C-3 AMIDOETHANE SIDE-CHAIN

被引：59

作者：

GARRATT, PJ

VONHOFF, S

ROWE, SJ

SUGDEN, D

机构：

[1] UNIV LONDON UNIV COLL,DEPT ANAT & DEV BIOL,LONDON WC1E 6BT,ENGLAND

[2] KINGS COLL LONDON,DIV BIOMED SCI,PHYSIOL GRP,LONDON W8 7AH,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(01)80566-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of indole derived melatonin analogues have been prepared with the C-3 amidoethane side chain partially constrained by incorporation in a ring. The biological activity has been correlated with the conformation of the ''side chain'', the nature of the N-acylating group, and the spatial distance between the methoxyl and amide functions.

引用

页码：1559 / 1564

页数：6

共 20 条

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