IDENTIFICATION OF CIS-3'-HYDROXYCOTININE AS A URINARY NICOTINE METABOLITE

被引:14
作者
VONCKEN, P
RUSTEMEIER, K
SCHEPERS, G
机构
[1] INBIFO Institut für biologische Forschung, D-5000, Körln 90
关键词
D O I
10.3109/00498259009046633
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. cis-3'-Hydroxycotinine was detected as an S(-)-nicotine metabolite in the urine of smokers as well as in the urine of rats and hamsters dosed with nicotine. 2. The excreted amount of cis-3'-hydroxycotinine is lower than that of the trans-isomer. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码:1353 / 1356
页数:4
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[11]   CAPILLARY GAS-CHROMATOGRAPHIC DETERMINATION OF TRANS-3'-HYDROXYCOTINE SIMULTANEOUSLY WITH NICOTINE AND COTININE IN URINE AND BLOOD-SAMPLES [J].
VONCKEN, P ;
SCHEPERS, G ;
SCHAFER, KH .
JOURNAL OF CHROMATOGRAPHY, 1989, 479 (02) :410-418