SUPPRESSION OF THE IMMUNE-RESPONSE BY A SOLUBLE COMPLEMENT RECEPTOR OF LYMPHOCYTES-B

被引：231

作者：

HEBELL, T

AHEARN, JM

FEARON, DT

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV MOLEC & CLIN RHEUMATOL, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS UNIV, SCH MED, GRAD PROGRAM IMMUNOL, BALTIMORE, MD 21205 USA

来源：

SCIENCE | 1991年 / 254卷 / 5028期

关键词：

D O I：

10.1126/science.1718035

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The CD19-CR2 complex of B lymphocytes contains proteins that participate in two host-defense systems, the immune and complement systems. The ligand for the subunit of the immune system, CD19, is not known, but the complement receptor subunit, CR2 (CD21), binds activation fragments of the C3 component of the complement system and may mediate immunopotentiating effects of complement. A recombinant, soluble CR2 was prepared by fusing the C3-binding region of the receptor to immunoglobulin G1 (IgG1). The (CR2)2-IgG1 chimera competed with cellular CR2 for C3 binding and suppressed the antibody response to a T cell-dependent antigen when administered to mice at the time of immunization. This inhibitory effect of (CR2)2-IgG1 demonstrates the B cell-activating function of the CD19-CR2 complex and suggests a new method for humoral immunosuppression.

引用

页码：102 / 105

页数：4

共 30 条

[21]

MARTINELLI GP, 1978, J IMMUNOL, V121, P2043

[22] INTERSECTION OF THE COMPLEMENT AND IMMUNE-SYSTEMS - A SIGNAL TRANSDUCTION COMPLEX OF THE LYMPHOCYTE-B CONTAINING COMPLEMENT RECEPTOR TYPE-2 AND CD19 [J].