It's all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection

被引：13

作者：

Leung, Philberta Y. ^{[1
]}

Packard, Amy E. B. ^{[1
]}

Stenzel-Poore, Mary P. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol L220, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

来源：

FUTURE NEUROLOGY | 2009年 / 4卷 / 02期

关键词：

ischemic tolerance; preconditioning; stroke; Toll-like receptors;

D O I：

10.2217/14796708.4.2.201

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ischemic tolerance is a biological process that can be utilized to unlock the brain's own endogenous protection mechanisms and, as such, holds true promise for patients at risk of ischemic injury. Experimentally, preconditioning with various Toll-like receptor (TLR) agonists has now been demonstrated to successfully attenuate ischemic damage, partly through genomic reprogramming of the body's response to stroke. This treatment diminishes the inflammatory response to stroke and at the same time enhances the production of anti-inflammatory cytokines and neuroprotective mediators. This review discusses recent discoveries about the role of TLRs in preconditioning and ischemic tolerance.

引用

页码：201 / 208

页数：8

共 64 条

[1] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L
Holt, AC
Medzhitov, R
Flavell, RA
[J]. NATURE, 2001, 413 (6857) : 732 - 738
[2] Toll-like receptor 2 is protective of ischemia-reperfusion-mediated small-bowel injury in a murine model
Aprahamian, Charles J.
Lorenz, Robin G.
Harmon, Carroll M.
Dimmit, Reed A.
[J]. PEDIATRIC CRITICAL CARE MEDICINE, 2008, 9 (01) : 105 - 109
[3] TOLL-LIKE RECEPTORS IN ISCHEMIA-REPERFUSION INJURY
Arumugam, Thiruma V.
Okun, Eitan
Tang, Sung-Chun
Thundyil, John
Taylor, Stephen M.
Woodruff, Trent M.
[J]. SHOCK, 2009, 32 (01): : 4 - 16
[4] Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus
Barrat, FJ
Meeker, T
Gregorio, J
Chan, JH
Uematsu, S
Akira, S
Chang, B
Duramad, O
Coffman, RL
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (08) : 1131 - 1139
[5] Increase in endogenous brain superoxide dismutase as a potential mechanism of lipopolysaccharide-induced brain ischemic tolerance
Bordet, R
Deplanque, D
Maboudou, P
Puisieux, F
Pu, Q
Robin, E
Martin, A
Bastide, M
Leys, D
Lhermitte, M
Dupuis, B
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (08) : 1190 - 1196
[6] The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
Bowie, A
O'Neill, LAJ
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2000, 67 (04) : 508 - 514
[7] ENDOTOXIN PRETREATMENT INCREASES ENDOGENOUS MYOCARDIAL CATALASE ACTIVITY AND DECREASES ISCHEMIA REPERFUSION INJURY OF ISOLATED RAT HEARTS
BROWN, JM
GROSSO, MA
TERADA, LS
WHITMAN, GJR
BANERJEE, A
WHITE, CW
HARKEN, AH
REPINE, JE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) : 2516 - 2520
[8] Broad expression of Toll-like receptors in the human central nervous system
Bsibsi, M
Ravid, R
Gveric, D
van Noort, JM
[J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2002, 61 (11) : 1013 - 1021
[9] Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators
Bsibsi, M
Persoon-Deen, C
Verwer, RWH
Meeuwsen, S
Ravid, R
Van Noort, JM
[J]. GLIA, 2006, 53 (07) : 688 - 695
[10] Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals
Cameron, Jill S.
Alexopoulou, Lena
Sloane, Jacob A.
DiBernardo, Allitia B.
Ma, Yinghua
Kosaras, Bela
Flavell, Richard
Strittmatter, Stephen M.
Volpe, Joseph
Sidman, Richard
Vartanian, Timothy
[J]. JOURNAL OF NEUROSCIENCE, 2007, 27 (47) : 13033 - 13041

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