It's all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection

被引：13

作者：

Leung, Philberta Y. ^{[1
]}

Packard, Amy E. B. ^{[1
]}

Stenzel-Poore, Mary P. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol L220, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

来源：

FUTURE NEUROLOGY | 2009年 / 4卷 / 02期

关键词：

ischemic tolerance; preconditioning; stroke; Toll-like receptors;

D O I：

10.2217/14796708.4.2.201

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ischemic tolerance is a biological process that can be utilized to unlock the brain's own endogenous protection mechanisms and, as such, holds true promise for patients at risk of ischemic injury. Experimentally, preconditioning with various Toll-like receptor (TLR) agonists has now been demonstrated to successfully attenuate ischemic damage, partly through genomic reprogramming of the body's response to stroke. This treatment diminishes the inflammatory response to stroke and at the same time enhances the production of anti-inflammatory cytokines and neuroprotective mediators. This review discusses recent discoveries about the role of TLRs in preconditioning and ischemic tolerance.

引用

页码：201 / 208

页数：8

共 64 条

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