DIMINISHED GENOTOXICITY OF MITOMYCIN-C AND FARMORUBICIN INCLUDED IN POLYBUTYLCYANOACRYLATE NANOPARTICLES

被引：10

作者：

BLAGOEVA, PM ^{[1
]}

BALANSKY, RM ^{[1
]}

MIRCHEVA, TJ ^{[1
]}

SIMEONOVA, MI ^{[1
]}

机构：

[1] SCI RES CTR SPECIAL POLYMERS,BU-1756 SOFIA,BULGARIA

来源：

MUTATION RESEARCH | 1992年 / 268卷 / 01期

关键词：

MUTAGENICITY; CLASTOGENICITY; TRANSPLACENTAL TRANSPORT; MITOMYCIN-C; FARMORUBICIN; POLYBUTYLCYANOACRYLATE NANOPARTICLES;

D O I：

10.1016/0027-5107(92)90085-G

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genotoxic effects of mitomycin C (MMC) and farmorubicin (FR) in a free form and included in polybutylcyanoacrylate nanoparticles (PBCN) were studied employing the Salmonella/microsome mutagenicity assay and the micronucleus test in mouse bone marrow as well as in mouse fetal liver. The data obtained clearly indicated that MMC (0.25-2.00-mu-g/plate) was a strong mutagen in S. typhimurium TA102, while the same concentrations of this compound in PBCN were ineffective in inducing his+ revertant mutations in bacterial cells. A similar total suppression of mutagenic activity of FR (1.0-20.0-mu-g/plate) was registered in S. typhimurium TA98 when the drug was included in PBCN. Furthermore, the incorporation of MMC (2.0 or 4.0 mg/kg. i.p.) into PBCN strongly diminished or even abolished its clastogenic activity in the bone marrow of virgin and pregnant mice as well as in mouse fetal liver, respectively. In addition, a lack of genotoxic effect of PBCN only was also established. The toxic activity of MMC in mouse bone marrow was significantly reduced or completely abolished after its inclusion in PBCN. A conclusion might be drawn that the genotoxic activity of some antitumor drugs might be markedly diminished or even abolished after their incorporation in PBCN.

引用

页码：77 / 82

页数：6