NITRO-L-ARGININE AUGMENTS THE ENDOTHELIN-1 CONTENT OF CEREBROSPINAL-FLUID INDUCED BY CEREBRAL-ISCHEMIA

被引：20

作者：

SPATZ, M

STANIMIROVIC, D

STRASSER, A

MCCARRON, RM

机构：

[1] National Institutes of Health, Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda

来源：

BRAIN RESEARCH | 1995年 / 684卷 / 01期

关键词：

NITRO-L-ARGININE; ENDOTHELIN-1; CEREBROSPINAL FLUID; CEREBRAL ISCHEMIA REPERFUSION;

D O I：

10.1016/0006-8993(95)00438-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of nitro-L-arginine (NLA), inhibitor of NO synthase, on ET-1 content in cerebrospinal fluid (CSF) and on the vascular system was investigated in global ischemia/reperfusion of Mongolian gerbils. The results indicate that NLA induced a prolonged (2-3-fold) increase of ET-1 concentration above that seen in the CSF of untreated animals during ischemia/reperfusion. Both the transient and prolonged rise of ET-1 content observed in the CSF coincided with the reduction in the cerebral blood flow seen in untreated and NLA-treated gerbils, respectively, at the time of reperfusion.

引用

页码：99 / 102

页数：4