THE ROLE OF AMYLOID BETA-PROTEIN IN ALZHEIMER-DISEASE

被引：67

作者：

REGLAND, B ^{[1
]}

GOTTFRIES, CG ^{[1
]}

机构：

[1] MOLNDAL CTY HOSP,DEPT NEUROCHEM,S-43180 MOLNDAL,SWEDEN

来源：

LANCET | 1992年 / 340卷 / 8817期

关键词：

D O I：

10.1016/0140-6736(92)91780-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Deposition of amyloid beta-protein in the brain has been regarded as the central event in Alzheimer's disease; however, amyloid beta-protein precursor is an endogenous protein, probably with neurotrophic functions. An alternative hypothesis is that amyloid beta-protein is involved in the disease process secondarily, as a protective reactant when brain cells are injured. Insufficiency of amyloid beta-protein precursor, whether because of a genetic defect or in relation to the action of environmental factors, then allows development of Alzheimer changes.

引用

页码：467 / 469

页数：3

共 31 条

[1] INDUCTION OF AMYLOID PRECURSOR PROTEIN MESSENGER-RNA AFTER HEAT-SHOCK IN CULTURED HUMAN LYMPHOBLASTOID-CELLS [J].

ABE, K ;

STGEORGEHYSLOP, PH ;

TANZI, RE ;

KOGURE, K .

NEUROSCIENCE LETTERS, 1991, 125 (02) :169-171

[2] SELECTIVE INDUCTION OF KUNITZ-TYPE PROTEASE INHIBITOR DOMAIN-CONTAINING AMYLOID PRECURSOR PROTEIN MESSENGER-RNA AFTER PERSISTENT FOCAL ISCHEMIA IN RAT CEREBRAL-CORTEX [J].

ABE, K ;

TANZI, RE ;

KOGURE, K .

NEUROSCIENCE LETTERS, 1991, 125 (02) :172-174

[3] IMMUNOHISTOCHEMICAL EVIDENCE FOR THE DERIVATION OF A PEPTIDE LIGAND FROM THE AMYLOID BETA-PROTEIN PRECURSOR OF ALZHEIMER-DISEASE [J].

ALLSOP, D ;

WONG, CW ;

IKEDA, S ;

LANDON, M ;

KIDD, M ;

GLENNER, GG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) :2790-2794

[4]

BUSH AI, 1990, J BIOL CHEM, V265, P15977

[5] STIMULATED PLATELETS RELEASE AMYLOID BETA-PROTEIN PRECURSOR [J].

COLE, GM ;

GALASKO, D ;

SHAPIRO, IP ;

SAITOH, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 170 (01) :288-295

[6] CLINICOPATHOLOGIC STUDIES IN DEMENTIA - NONDEMENTED SUBJECTS WITH PATHOLOGICALLY CONFIRMED ALZHEIMERS-DISEASE [J].

CRYSTAL, H ;

DICKSON, D ;

FULD, P ;

MASUR, D ;

SCOTT, R ;

MEHLER, M ;

MASDEU, J ;

KAWAS, C ;

ARONSON, M ;

WOLFSON, L .

NEUROLOGY, 1988, 38 (11) :1682-1687

[7] LARGE AMOUNTS OF NEOCORTICAL BETA-A4 DEPOSITS WITHOUT NEURITIC PLAQUES NOR TANGLES IN A PSYCHOMETRICALLY ASSESSED, NONDEMENTED PERSON [J].

DELAERE, P ;

DUYCKAERTS, C ;

MASTERS, C ;

BEYREUTHER, K ;

PIETTE, F ;

HAUW, JJ .

NEUROSCIENCE LETTERS, 1990, 116 (1-2) :87-93

[8] DIFFUSE LEWY BODY DISEASE - LIGHT AND ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMISTRY OF SENILE PLAQUES [J].

DICKSON, DW ;

CRYSTAL, H ;

MATTIACE, LA ;

KRESS, Y ;

SCHWAGERL, A ;

KSIEZAKREDING, H ;

DAVIES, P ;

YEN, SHC .

ACTA NEUROPATHOLOGICA, 1989, 78 (06) :572-584

[9] SEGREGATION OF A MISSENSE MUTATION IN THE AMYLOID PRECURSOR PROTEIN GENE WITH FAMILIAL ALZHEIMERS-DISEASE [J].

GOATE, A ;

CHARTIERHARLIN, MC ;

MULLAN, M ;

BROWN, J ;

CRAWFORD, F ;

FIDANI, L ;

GIUFFRA, L ;

HAYNES, A ;

IRVING, N ;

JAMES, L ;

MANT, R ;

NEWTON, P ;

ROOKE, K ;

ROQUES, P ;

TALBOT, C ;

PERICAKVANCE, M ;

ROSES, A ;

WILLIAMSON, R ;

ROSSOR, M ;

OWEN, M ;

HARDY, J .

NATURE, 1991, 349 (6311) :704-706

[10] AMYLOID DEPOSITION AS THE CENTRAL EVENT IN THE ETIOLOGY OF ALZHEIMERS-DISEASE [J].

HARDY, J ;

ALLSOP, D .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (10) :383-388

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