THE ROLE OF AMYLOID BETA-PROTEIN IN ALZHEIMER-DISEASE

被引：67

作者：

REGLAND, B ^{[1
]}

GOTTFRIES, CG ^{[1
]}

机构：

[1] MOLNDAL CTY HOSP,DEPT NEUROCHEM,S-43180 MOLNDAL,SWEDEN

来源：

LANCET | 1992年 / 340卷 / 8817期

关键词：

D O I：

10.1016/0140-6736(92)91780-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Deposition of amyloid beta-protein in the brain has been regarded as the central event in Alzheimer's disease; however, amyloid beta-protein precursor is an endogenous protein, probably with neurotrophic functions. An alternative hypothesis is that amyloid beta-protein is involved in the disease process secondarily, as a protective reactant when brain cells are injured. Insufficiency of amyloid beta-protein precursor, whether because of a genetic defect or in relation to the action of environmental factors, then allows development of Alzheimer changes.

引用

页码：467 / 469

页数：3