学术探索
学术期刊
新闻热点
数据分析
智能评审

CLONING, CHROMOSOMAL LOCATION AND FUNCTIONAL EXPRESSION OF THE HUMAN VOLTAGE-DEPENDENT CALCIUM-CHANNEL BETA-3 SUBUNIT

被引：54
作者：
COLLIN, T
LORY, P
TAVIAUX, S
COURTIEU, C
GUILBAULT, P
BERTA, P
NARGEOT, J
机构：
[1] CTR RECH BIOCHEM MACROMOLEC,CNRS,UPR 9008,INSERM,U249,F-34003 MONTPELLIER,FRANCE
[2] HOP CARREMEAU,SERV GYNECOL OBSTET,NIMES,FRANCE
[3] UNIV SCI & TECH LILLE FLANDRES ARTOIS,PHYSIOL CELLULAIRE LAB,VILLENEUVE DASCQ,FRANCE
来源：
EUROPEAN JOURNAL OF BIOCHEMISTRY | 1994年 / 220卷 / 01期
关键词：
D O I：
10.1111/j.1432-1033.1994.tb18621.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel human-voltage-dependent-calcium-channel (VDCC) beta subunit was isolated from a 9-week-old human total-embryo cDNA library. Of the four genes encoding beta-subunit isoforms that have been identified in animal species, this isoform shares strong similarity with the rat and rabbit beta(3)-related gene product and is referred to here as H beta(3) subunit. The H beta(3) isoform is the second beta subunit identified in human. Its open reading frame encodes a 482-amino-acid protein with a predicted molecular mass of 54.571 kDa. The H beta(3) mRNA is expressed mostly in brain, smooth muscle and ovary. The gene for the human H beta(3) was specifically localized on chromosome 12q13. The cloned H beta(3) subunit was further expressed in Xenopus oocytes to demonstrate its ability to modulate VDCC activity.
引用
收藏
页码：257 / 262
页数：6
相关论文
共 31 条
[1]   SUBUNIT STRUCTURE AND LOCALIZATION OF DIHYDROPYRIDINE-SENSITIVE CALCIUM CHANNELS IN MAMMALIAN BRAIN, SPINAL-CORD, AND RETINA [J].
AHLIJANIAN, MK ;
WESTENBROEK, RE ;
CATTERALL, WA .
NEURON, 1990, 4 (06) :819-832
[2]   ENDOGENOUS XENOPUS-OOCYTE CA-CHANNELS ARE REGULATED BY PROTEIN KINASE-A AND KINASE-C [J].
BOURINET, E ;
FOURNIER, F ;
NARGEOT, J ;
CHARNET, P .
FEBS LETTERS, 1992, 299 (01) :5-9
[3]  
CASTELLANO A, 1993, J BIOL CHEM, V268, P12359
[4]  
CASTELLANO A, 1993, J BIOL CHEM, V268, P3450
[5]  
CATTERALL WA, 1988, J BIOL CHEM, V263, P3535
[6]   FUNCTIONAL SUBUNIT STRUCTURE OF VOLTAGE-GATED CALCIUM CHANNELS [J].
CATTERALL, WA .
SCIENCE, 1991, 253 (5027) :1499-1500
[7]   SIMULTANEOUS LOCALIZATION OF COSMIDS AND CHROMOSOME R-BANDING BY FLUORESCENCE MICROSCOPY - APPLICATION TO REGIONAL MAPPING OF HUMAN CHROMOSOME-11 [J].
CHERIF, D ;
JULIER, C ;
DELATTRE, O ;
DERRE, J ;
LATHROP, GM ;
BERGER, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6639-6643
[8]   MOLECULAR-CLONING OF 3 ISOFORMS OF THE L-TYPE VOLTAGE-DEPENDENT CALCIUM-CHANNEL BETA-SUBUNIT FROM NORMAL HUMAN HEART [J].
COLLIN, T ;
WANG, JJ ;
NARGEOT, J ;
SCHWARTZ, A .
CIRCULATION RESEARCH, 1993, 72 (06) :1337-1344
[9]   ASSIGNMENT OF THE HUMAN GENE FOR THE BETA-SUBUNIT OF THE VOLTAGE-DEPENDENT CALCIUM-CHANNEL (CACNLB1) TO CHROMOSOME-17 USING SOMATIC-CELL HYBRIDS AND LINKAGE MAPPING [J].
GREGG, RG ;
POWERS, PA ;
HOGAN, K .
GENOMICS, 1993, 15 (01) :185-187
[10]   CALCIUM-CHANNEL BETA-SUBUNIT HETEROGENEITY - FUNCTIONAL EXPRESSION OF CLONED CDNA FROM HEART, AORTA AND BRAIN [J].
HULLIN, R ;
SINGERLAHAT, D ;
FREICHEL, M ;
BIEL, M ;
DASCAL, N ;
HOFMANN, F ;
FLOCKERZI, V .
EMBO JOURNAL, 1992, 11 (03) :885-890
1234