NASAL ADMINISTRATION OF NALOXONE IS AS EFFECTIVE AS THE INTRAVENOUS ROUTE IN OPIATE ADDICTS

被引:47
作者
LOIMER, N
HOFMANN, P
CHAUDHRY, HR
机构
[1] GRAZ UNIV,DEPT PSYCHIAT,A-8036 GRAZ,AUSTRIA
[2] PUNJAB UNIV,FATIMA JINNAH MED COLL,DEPT PSYCHIAT,LAHORE,PAKISTAN
来源
INTERNATIONAL JOURNAL OF THE ADDICTIONS | 1994年 / 29卷 / 06期
关键词
NALOXONE; OPIATE ADDICTION; NASAL ADMINISTRATION; INTRAVENOUS APPLICATION;
D O I
10.3109/10826089409047912
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Naloxone is used intravenously in opiate addiction in emergency cases, in rapid opiate detoxification, and as a diagnostic tool. This is a study comparing the efficacy of intranasal naloxone to other routes (intravenous/intramuscular) in 17 opiate-dependent patients. The nasal drug administration of naloxone was found to be as effective as the intravenous route. The nasal drug application offers a wide margin of safety for patients and medical staff, especially in emergency situations in regard to infection risks associated with vessel puncture.
引用
收藏
页码:819 / 827
页数:9
相关论文
共 13 条
[1]  
CLAUSS G, 1985, STATISTIK
[2]  
CREIGHTON FJ, 1989, LANCET, P748
[3]  
FISHMAN J, 1973, J PHARMACOL EXP THER, V187, P575
[4]   NASAL ABSORPTION OF NALOXONE AND BUPRENORPHINE IN RATS [J].
HUSSAIN, A ;
KIMURA, R ;
HUANG, CH ;
KASHIHARA, T .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1984, 21 (02) :233-237
[5]   BUCCAL AND ORAL BIOAVAILABILITY OF NALOXONE AND NALTREXONE IN RATS [J].
HUSSAIN, MA ;
AUNGST, BJ ;
KEARNEY, A ;
SHEFTER, E .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 36 (2-3) :127-130
[6]   NALOXONE INDUCES MIOSIS IN NORMAL SUBJECTS [J].
LOIMER, N ;
SCHMID, R ;
GRUNBERGER, J ;
LINZMAYER, L .
PSYCHOPHARMACOLOGY, 1990, 101 (02) :282-283
[7]   COMPARISON BETWEEN OBSERVER ASSESSMENT AND SELF RATING OF WITHDRAWAL DISTRESS DURING OPIATE DETOXIFICATION [J].
LOIMER, N ;
LINZMAYER, L ;
GRUNBERGER, J .
DRUG AND ALCOHOL DEPENDENCE, 1991, 28 (03) :265-268
[8]   ACUTE BLOCKING OF NALOXONE-PRECIPITATED OPIATE WITHDRAWAL SYMPTOMS BY METHOHEXITONE [J].
LOIMER, N ;
SCHMID, R ;
LENZ, K ;
PRESSLICH, O ;
GRUNBERGER, J .
BRITISH JOURNAL OF PSYCHIATRY, 1990, 157 :748-752
[9]  
LOIMER N, 1990, LANCET, P1107
[10]   NALOXONE [J].
MARTIN, WR .
ANNALS OF INTERNAL MEDICINE, 1976, 85 (06) :765-768