WHOLE COMPLEMENT HEMOLYTIC-ACTIVITY (CH50) FOLLOWING INFUSION OF STROMA-FREE AND POLYHEMOGLOBIN SOLUTIONS IN RATS

被引：4

作者：

NING, J

CHANG, TMS

机构：

[1] Artificial Cells and Organs Research Centre McGill University, Montreal

来源：

BIOMATERIALS ARTIFICIAL CELLS AND ARTIFICIAL ORGANS | 1990年 / 18卷 / 02期

基金：

英国医学研究理事会;

关键词：

complement activation; polyhemoglobin; stroma-free hemoglobin;

D O I：

10.3109/10731199009117302

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We developed a method to determine whole complement hemolytic activity(CH50)in rat plasma using a modification of the method of Mayer(l). Plasma CH50 level in 30 male Sprague Dawley rats was 1000+200 units. Following infusions with human and rat stroma-free hemoglobin or polyhemoglobin solutions, CH50 did not change significantly in rats when compared to albumin infused rats. On the other hand, CH50 significantly decreased in the group receiving membrane stroma and bacterial endotoxins. © 1990, Informa UK Ltd. All rights reserved.

引用

页码：203 / 217

页数：15

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