AN EFFICIENT AND PRACTICAL SYNTHESIS OF L-ALPHA-AMINO ACIDS USING (R)-PHENYLGLYCINOL AS A CHIRAL AUXILIARY

被引：51

作者：

INABA, T

KOZONO, I

FUJITA, M

OGURA, K

机构：

[1] CHIBA UNIV, FAC ENGN, DEPT APPL CHEM, 1-33 YAYOICHO, INAGE KU, CHIBA 263, JAPAN

[2] CHIBA UNIV, GRAD SCH SCI & TECHNOL, INAGE KU, CHIBA 263, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1992年 / 65卷 / 09期

关键词：

D O I：

10.1246/bcsj.65.2359

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

L-alpha-Amino acids including L-alpha-arylglycines were conveniently and stereoselectively synthesized via the alpha-amino carbonitriles given by the Strecker reaction of (R)-2-amino-2-phenylethanol with aldehydes and hydrogen cyanide. The stereoselectivity of these alpha-amino carbonitriles was thermodynamically controlled.

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页码：2359 / 2365

页数：7

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