VASOPRESSIN AND OXYTOCIN MODULATION OF MELATONIN SECRETION FROM RAT PINEAL GLANDS

被引：33

作者：

SIMONNEAUX, V

OUICHOU, A

BURBACH, JPH

PEVET, P

机构：

[1] UNIV STRASBOURG 1,CNRS,UNITE NEUROBIOL FONCT RYTHM & SAISONNIERES 1332,12 RUE UNIV,F-67070 STRASBOURG,FRANCE

[2] STATE UNIV UTRECHT,FAC MED,RUDOLF MAGNUS INST,3521 GD UTRECHT,NETHERLANDS

来源：

PEPTIDES | 1990年 / 11卷 / 06期

关键词：

PINEAL GLAND; MELATONIN; PERIFUSION; VASOPRESSIN; OXYTOCIN;

D O I：

10.1016/0196-9781(90)90133-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rat pineal gland is known to release melatonin in response to noradrenergic stimulation. Since vasopressin (VP)- and oxytocin (OT)-containing fibers innervate the pineal gland, the effects of VP and OT on melatonin release from perifused rat pineal glands were investigated. VP(10(-7) M) and OT (10(-6) M) decreased the basal melatonin secretion. No dose-dependent effect was observed. At high concentrations (10(-5)) these peptide potentiated the isoproterenol-induced increase of melatonin secretion. Below 10(-5) M no potentiation was observed. Fragments of VP {[pGlu4, Cys6]VP(4-9)} and OT [{pGlu4, Cys6]OT(4-9)} did not display any effect on the isoproterenol-induced melatonin secretion.

引用

页码：1075 / 1079

页数：5

共 33 条

[1]

Arendt J., 1985, Pineal Research Reviews, V3, P161

[2]

BRINTON RE, 1989, J NEUROSCI, V9, P752

[3]

BUIJS RM, 1980, CELL TISSUE RES, V205, P11

[4] A MAJOR METABOLITE OF ARGININE VASOPRESSIN IN THE BRAIN IS A HIGHLY POTENT NEUROPEPTIDE [J].

BURBACH, JPH ;

KOVACS, GL ;

DEWIED, D ;

VANNISPEN, JW ;

GREVEN, HM .

SCIENCE, 1983, 221 (4617) :1310-1312

[5]

BURBACH JPH, 1987, VASOPRESSIN PRINCIPL, P497

[6] VASOPRESSIN AFFECTS ADENYLATE-CYCLASE ACTIVITY IN RAT-BRAIN - A POSSIBLE NEUROMODULATOR [J].

COURTNEY, N ;

RASKIND, M .

LIFE SCIENCES, 1983, 32 (06) :591-596

[7] AUTORADIOGRAPHIC LOCALIZATION OF BINDING-SITES FOR THE ARGININE-VASOPRESSIN (VP) METABOLITE, VP4-9, IN RAT-BRAIN [J].

DEKLOET, ER ;

VOORHUIS, TAM ;

BURBACH, JPH ;

DEWIED, D .

NEUROSCIENCE LETTERS, 1985, 56 (01) :7-11

[8] STUDIES ON THE PRESENCE OF VASOPRESSIN, OXYTOCIN AND VASOTOCIN IN THE PINEAL-GLAND, SUB-COMMISSURAL ORGAN AND FETAL PITUITARY-GLAND - FAILURE TO DEMONSTRATE VASOTOCIN IN MAMMALS [J].

DOGTEROM, J ;

SNIJDEWINT, FGM ;

PEVET, P ;

SWAAB, DF .

JOURNAL OF ENDOCRINOLOGY, 1980, 84 (01) :115-123

[9] STIMULATION OF PHOSPHOINOSITIDE HYDROLYSIS BY OXYTOCIN AND THE MECHANISM BY WHICH OXYTOCIN CONTROLS PROSTAGLANDIN SYNTHESIS IN THE OVINE ENDOMETRIUM [J].

FLINT, APF ;

LEAT, WMF ;

SHELDRICK, EL ;

STEWART, HJ .

BIOCHEMICAL JOURNAL, 1986, 237 (03) :797-805

[10]

GOVITRAPONG P, 1985, ENDOCR RES, V12, P293

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