VASOPRESSIN AND OXYTOCIN MODULATION OF MELATONIN SECRETION FROM RAT PINEAL GLANDS

被引：33

作者：

SIMONNEAUX, V

OUICHOU, A

BURBACH, JPH

PEVET, P

机构：

[1] UNIV STRASBOURG 1,CNRS,UNITE NEUROBIOL FONCT RYTHM & SAISONNIERES 1332,12 RUE UNIV,F-67070 STRASBOURG,FRANCE

[2] STATE UNIV UTRECHT,FAC MED,RUDOLF MAGNUS INST,3521 GD UTRECHT,NETHERLANDS

来源：

PEPTIDES | 1990年 / 11卷 / 06期

关键词：

PINEAL GLAND; MELATONIN; PERIFUSION; VASOPRESSIN; OXYTOCIN;

D O I：

10.1016/0196-9781(90)90133-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rat pineal gland is known to release melatonin in response to noradrenergic stimulation. Since vasopressin (VP)- and oxytocin (OT)-containing fibers innervate the pineal gland, the effects of VP and OT on melatonin release from perifused rat pineal glands were investigated. VP(10(-7) M) and OT (10(-6) M) decreased the basal melatonin secretion. No dose-dependent effect was observed. At high concentrations (10(-5)) these peptide potentiated the isoproterenol-induced increase of melatonin secretion. Below 10(-5) M no potentiation was observed. Fragments of VP {[pGlu4, Cys6]VP(4-9)} and OT [{pGlu4, Cys6]OT(4-9)} did not display any effect on the isoproterenol-induced melatonin secretion.

引用

页码：1075 / 1079

页数：5

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