VANADIUM DERIVATIVES ACT AS GROWTH-FACTOR - MIMETIC COMPOUNDS UPON DIFFERENTIATION AND PROLIFERATION OF OSTEOBLAST-LIKE UMR106 CELLS

被引：108

作者：

CORTIZO, AM

ETCHEVERRY, SB

机构：

[1] NATL UNIV LA PLATA,FAC CIENCIAS EXACTAS,CATEDRA BIOQUIM PATOL,RA-1900 LA PLATA,ARGENTINA

[2] NATL UNIV LA PLATA,FAC CIENCIAS EXACTAS,PROGRAMA QUINOR,RA-1900 LA PLATA,ARGENTINA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1995年 / 145卷 / 02期

关键词：

VANADIUM COMPOUNDS; OSTEOBLAST-LIKE CELLS; PROLIFERATION; DIFFERENTIATION; BONE DEVELOPMENT; GROWTH FACTORS;

D O I：

10.1007/BF00935481

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The effect of different vanadium compounds on proliferation and differentiation was examined in osteoblast-like UMR106 cells. Vanadate increased the cell growth in a biphasic manner, the higher doses inhibiting cell progression. Vanadyl stimulated cell proliferation in a dose-responsive manner. Similar to vanadate, pervanadate increased osteoblast-like cell proliferation in a biphasic manner but no inhibition of growth was observed. Vanadyl and pervanadate were stronger stimulators of cell growth than vanadate. Only vanadate was able to regulate the cell differentiation as measured by cell alkaline phosphatase activity. These results suggest that vanadium derivatives behave like growth factors on osteoblast-like cells and are potential pharmacological tools in the control of cell growth.

引用

页码：97 / 102

页数：6

共 28 条

[21]

PARTRIDGE NC, 1983, CANCER RES, V43, P4308

[22] INSULIN-LIKE GROWTH-FACTORS STIMULATE SYNTHESIS OF NUCLEIC-ACIDS AND GLYCOGEN IN CULTURED CALVARIA CELLS [J].