CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF BACLOFEN

被引：42

作者：

CHENEVERT, R

DESJARDINS, M

机构：

[1] Département de Chimie, Faculté des Sciences, Génie Université Laval

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 34期

基金：

加拿大自然科学与工程研究理事会;

关键词：

BACLOFEN; ENANTIOMERS; CHEMOENZYMATIC SYNTHESIS; CHYMOTRYPSIN; ASYMMETRIC SYNTHESIS;

D O I：

10.1016/S0040-4039(00)92140-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both enantiomers of baclofen have been synthesized in five steps from 4-chlorocinnamic acid. The key step is the highly stereoselective enzymatic hydrolysis of dimethyl 3-(4-chlorophenyl)glutarate by chymotrypsin.

引用

页码：4249 / 4250

页数：2

共 4 条

[1] STRUCTURE AND ABSOLUTE-CONFIGURATION OF (R)-BACLOFEN MONOHYDROCHLORIDE
CHANG, CH
YANG, DSC
YOO, CS
WANG, BC
PLETCHER, J
SAX, M
TERRENCE, CF
[J]. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1982, 38 (JUL): : 2065 - 2067
[2] KRAPCHO AP, 1982, SYNTHESIS-STUTTGART, P805
[3] BIOLOGICAL-ACTIVITY OF D-BACLOFEN AND 1-BACLOFEN (LIORESAL)
OLPE, HR
DEMIEVILLE, H
BALTZER, V
BENCZE, WL
KOELLA, WP
WOLF, P
HAAS, HL
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 52 (01) : 133 - 136
[4] NEW METHOD FOR DIRECT CONVERSION OF AMIDES TO AMINES
RADHAKRISHNA, AS
PARHAM, ME
RIGGS, RM
LOUDON, GM
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (10) : 1746 - 1747

← 1 →