TOTAL SYNTHESIS OF (+)-TAUTOMYCIN

被引：40

作者：

ICHIKAWA, Y ^{[1
]}

TSUBOI, K ^{[1
]}

JIANG, YM ^{[1
]}

NAGANAWA, A ^{[1
]}

ISOBE, M ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH AGR SCI,ORGAN CHEM LAB,NAGOYA,AICHI 46401,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 39期

关键词：

D O I：

10.1016/0040-4039(95)01436-L

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tautomycin molecule was disconnected into 3 retrosynthetic segments, A, B and C, each of which was synthesized in optically active form. First coupling between Segments B and C was achieved between an epoxide and a sulfone carbanion in the presence of BF3 . OEt(2). This product (Segment B/C) and Segment A were further coupled by Yamaguchi esterification method. Final transformation of the furan ring into the maleic anhydride and removal of the protecting groups completed the total synthesis of (+)-tautomycin.

引用

页码：7101 / 7104

页数：4

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