THE ANTIOXIDANT ACTION OF TAMOXIFEN AND ITS METABOLITES - INHIBITION OF LIPID-PEROXIDATION

被引：77

作者：

WISEMAN, H

LAUGHTON, MJ

ARNSTEIN, HRV

CANNON, M

HALLIWELL, B

机构：

[1] Department of Biochemistry, University of London, King's College, London, WC2R 2LS, Strand Campus

来源：

FEBS LETTERS | 1990年 / 263卷 / 02期

关键词：

4-Hydroxytamoxifen; Antioxidant; Cancer; breast; Lipid peroxidation; Tamoxifen;

D O I：

10.1016/0014-5793(90)81371-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anti-oestrogen drug tamoxifen is an inhibitor of lipid peroxidation in rat liver microsomes and in phospholipid liposomes. Its cis isomer and N-desmethyl form are weaker inhibitors, but 4-hydroxytamoxifen is much more powerful. It is possible that the antioxidant property of tamoxifen might contribute to its biological actions. © 1990.

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页码：192 / 194

页数：3

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