THE GENOTOXICITY OF ORGANOTIN COMPOUNDS IN SOS CHROMOTEST AND REC-ASSAY

被引：27

作者：

HAMASAKI, T ^{[1
]}

SATO, T ^{[1
]}

NAGASE, H ^{[1
]}

KITO, H ^{[1
]}

机构：

[1] GIFU PHARMACEUT UNIV,DEPT PUBL HLTH,5-6-1 MITAHORAHIGASHI,GIFU 502,JAPAN

来源：

MUTATION RESEARCH | 1992年 / 280卷 / 03期

关键词：

ORGANOTIN COMPOUNDS; SOS CHROMOTEST; REC-ASSAY;

D O I：

10.1016/0165-1218(92)90049-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In these days pollution by organotin compounds in the environment extends widely and effects on human health are feared. We studied the genotoxicity of various organotin compounds (butyltins, phenyltins, methyltins) and inorganic tin (SnCl4), which are present in the environment, with the SOS chromotest and the rec-assay. Mono-n-butyltin oxide, n-butyltin trichloride and di-n-butyltin dichloride showed high SOS-inducing potency in the SOS chromotest with Escherichia coli PQ37. Di-n-butyltin dichloride, tri-n-butyltin chloride, bis(tri-n-butyltin)oxide, dimethyltin dichloride and trimethyltin chloride were recognized as genotoxic chemicals by the rec-assay.

引用

页码：195 / 203

页数：9

共 31 条

[11] PHENYLTINS IN WATER, SEDIMENT, AND BIOTA OF FRESH-WATER MARINAS
FENT, K
HUNN, J
[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1991, 25 (05) : 956 - 963
[12] FREQUENCY OF MICRONUCLEI INDUCED IN PERIPHERAL LYMPHOCYTES BY TRIMETHYLTIN CHLORIDE
GHOSH, BB
TALUKDER, G
SHARMA, A
[J]. MUTATION RESEARCH, 1990, 245 (01): : 33 - 39
[13] FREQUENCY OF CHROMOSOME-ABERRATIONS INDUCED BY TRIMETHYLTIN CHLORIDE IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES INVITRO - RELATED TO AGE OF DONORS
GHOSH, BB
TALUKDER, G
SHARMA, A
[J]. MECHANISMS OF AGEING AND DEVELOPMENT, 1991, 57 (02) : 125 - 137
[14] DETERMINATION OF PICOGRAM QUANTITIES OF METHYLTINS IN SEDIMENT
GILMOUR, CC
TUTTLE, JH
MEANS, JC
[J]. ANALYTICAL CHEMISTRY, 1986, 58 (08) : 1848 - 1852
[15] GUARD HE, 1982, SCIENCE, V213, P770
[16] ACUTE AND SUBLETHAL EFFECTS OF ORGANOTIN COMPOUNDS ON AQUATIC BIOTA - AN INTERPRETATIVE LITERATURE EVALUATION
HALL, LW
PINKNEY, AE
[J]. CRC CRITICAL REVIEWS IN TOXICOLOGY, 1985, 14 (02): : 159 - 209
[17] PRODUCTION OF METHYLTIN COMPOUNDS RELATED TO POSSIBLE CONDITIONS IN THE ENVIRONMENT
HAMASAKI, T
NAGASE, H
SATO, T
KITO, H
OSE, Y
[J]. APPLIED ORGANOMETALLIC CHEMISTRY, 1991, 5 (02) : 83 - 90
[18] REC-ASSAY WITH SPORES OF BACILLUS-SUBTILIS WITH AND WITHOUT METABOLIC-ACTIVATION
HIRANO, K
HAGIWARA, T
OHTA, Y
MATSUMOTO, H
KADA, T
[J]. MUTATION RESEARCH, 1982, 97 (05): : 339 - 347
[19] HOUK VS, 1989, MUTAT RES, V223, P49
[20] IN-VITRO AND HOST-MEDIATED REC-ASSAY PROCEDURES FOR SCREENING CHEMICAL MUTAGENS - AND PHLOXINE, A MUTAGENIC RED DYE DETECTED
KADA, T
TUTIKAWA, K
SADAIE, Y
[J]. MUTATION RESEARCH, 1972, 16 (02): : 165 - &

← 1 2 3 4 →