SCIENTIFIC AND SOCIAL-ISSUES OF HUMAN-IMMUNODEFICIENCY-VIRUS VACCINE DEVELOPMENT

被引:107
作者
HAYNES, BF [1 ]
机构
[1] DUKE CTR AIDS RES, DURHAM, NC 27710 USA
关键词
D O I
10.1126/science.8493572
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Development of a preventive immunogen for human immunodeficiency virus (HIV) infection is a national priority. The complexities associated with HIV host-virus interactions, coupled with the rapid progression of the HIV epidemic worldwide, have necessitated lowering expectations for an HIV vaccine that is 100 percent effective and have raised important scientific and nonscientific issues regarding development and use of preventive and therapeutic HIV vaccines.
引用
收藏
页码:1279 / 1286
页数:8
相关论文
共 158 条
[21]  
CHESNEY M, COMMUNICATION
[22]   CURRENT AND FUTURE DIMENSIONS OF THE HIV AIDS PANDEMIC IN WOMEN AND CHILDREN [J].
CHIN, J .
LANCET, 1990, 336 (8709) :221-224
[23]   THE ETHICAL DESIGN OF AN AIDS VACCINE TRIAL IN AFRICA [J].
CHRISTAKIS, NA .
HASTINGS CENTER REPORT, 1988, 18 (03) :31-37
[24]  
CIANCIOLO G, 1990, J IMMUNOL, V124, P2950
[25]   HIGH TITERS OF CYTOPATHIC VIRUS IN PLASMA OF PATIENTS WITH SYMPTOMATIC PRIMARY HIV-1 INFECTION [J].
CLARK, SJ ;
SAAG, MS ;
DECKER, WD ;
CAMPBELLHILL, S ;
ROBERSON, JL ;
VELDKAMP, PJ ;
KAPPES, JC ;
HAHN, BH ;
SHAW, GM .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (14) :954-960
[26]  
CLEMENTS ML, 1992, DEC I MED ROUNDT DEV
[27]   CELL-MEDIATED IMMUNE-RESPONSE TO HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) TYPE-1 IN SERONEGATIVE HOMOSEXUAL MEN WITH RECENT SEXUAL EXPOSURE TO HIV-1 [J].
CLERICI, M ;
GIORGI, JV ;
CHOU, CC ;
GUDEMAN, VK ;
ZACK, JA ;
GUPTA, P ;
HO, HN ;
NISHANIAN, PG ;
BERZOFSKY, JA ;
SHEARER, GM .
JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (06) :1012-1019
[28]  
COHEN J, 1992, SCIENCE, V258, P1729
[29]   NAKED DNA POINTS WAY TO VACCINES [J].
COHEN, J .
SCIENCE, 1993, 259 (5102) :1690-1692
[30]   AIDS FUNDING - DID POLITICAL CLOUT WIN VACCINE TRIAL FOR MICROGENESYS [J].
COHEN, J .
SCIENCE, 1992, 258 (5080) :211-211