CARBOXYL METHYLATION OF RAS-RELATED PROTEINS DURING SIGNAL TRANSDUCTION IN NEUTROPHILS

被引:202
作者
PHILIPS, MR
PILLINGER, MH
STAUD, R
VOLKER, C
ROSENFELD, MG
WEISSMANN, G
STOCK, JB
机构
[1] PRINCETON UNIV, DEPT CHEM, PRINCETON, NJ 08544 USA
[2] PRINCETON UNIV, DEPT MOLEC BIOL, PRINCETON, NJ 08544 USA
[3] NYU MED CTR, DEPT CELL BIOL, NEW YORK, NY 10016 USA
关键词
D O I
10.1126/science.8438158
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In human neutrophils, as in other cell types, Ras-related guanosine triphosphate binding proteins are directed toward their regulatory targets in membranes by a series of posttranslational modifications that include methyl esterification of a carboxyl-terminal prenylcysteine residue. In intact cells and in a reconstituted in vitro system, the amount of carboxyl methylation of Ras-related proteins increased in response to the chemoattractant N-formyl-methionyl-leucyl-phenylalanine (FMLP). Activation of Ras-related proteins by guanosine-5'-O-(3-thiotriphosphate) had a similar effect and induced translocation of p22rac2 from cytosol to plasma membrane. Inhibitors of prenylcysteine carboxyl methylation effectively blocked neutrophil responses to FMLP. These findings suggest a direct link between receptor-mediated signal transduction and the carboxyl methylation of Ras-related proteins.
引用
收藏
页码:977 / 980
页数:4
相关论文
共 38 条
[21]   REGULATION OF PHAGOCYTE OXYGEN RADICAL PRODUCTION BY THE GTP-BINDING PROTEIN RAC-2 [J].
KNAUS, UG ;
HEYWORTH, PG ;
EVANS, T ;
CURNUTTE, JT ;
BOKOCH, GM .
SCIENCE, 1991, 254 (5037) :1512-1515
[22]  
KORCHAK HM, 1984, J BIOL CHEM, V259, P4070
[23]   INCREASE IN THE EXPRESSION OF A FAMILY OF SMALL GUANOSINE TRIPHOSPHATE-BINDING PROTEINS, RAB PROTEINS, DURING INDUCED PHAGOCYTE DIFFERENTIATION [J].
MARIDONNEAUPARINI, I ;
YANG, CZ ;
BORNENS, M ;
GOUD, B .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (03) :901-907
[24]   RAPID STIMULATION OF PROTEIN CARBOXYMETHYLATION IN LEUKOCYTES BY A CHEMOTACTIC PEPTIDE [J].
ODEA, RF ;
VIVEROS, OH ;
AXELROD, J ;
ASWANKUMAR, S ;
SCHIFFMANN, E ;
CORCORAN, BA .
NATURE, 1978, 272 (5652) :462-464
[25]  
PHILIPS MR, 1991, J BIOL CHEM, V266, P1289
[26]   REQUIREMENT OF S-ADENOSYL-L-METHIONINE-MEDIATED METHYLATION FOR HUMAN MONOCYTE CHEMOTAXIS [J].
PIKE, MC ;
KREDICH, NM ;
SNYDERMAN, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (08) :3928-3932
[27]  
REIBMAN J, 1988, J BIOL CHEM, V263, P6322
[28]   CYTOCHROME-B558 - THE FLAVIN-BINDING COMPONENT OF THE PHAGOCYTE NADPH OXIDASE [J].
ROTROSEN, D ;
YEUNG, CL ;
LETO, TL ;
MALECH, HL ;
KWONG, CH .
SCIENCE, 1992, 256 (5062) :1459-1462
[29]  
SNYDERMAN R, 1988, INFLAMMATION BASIC P, P309
[30]   PROTEIN METHYLATION IN BEHAVIORAL-CONTROL MECHANISMS AND IN SIGNAL TRANSDUCTION [J].
SPRINGER, MS ;
GOY, MF ;
ADLER, J .
NATURE, 1979, 280 (5720) :279-284