ISOLATION AND CHARACTERIZATION OF NEW PORPHYRIN METABOLITES IN HUMAN PORPHYRIA-CUTANEA-TARDA AND IN RATS TREATED WITH HEXACHLOROBENZENE BY HPTLC, HPLC AND LIQUID SECONDARY-ION MASS-SPECTROMETRY

被引：23

作者：

LUO, JL ^{[1
]}

LIM, CK ^{[1
]}

机构：

[1] UNIV LEICESTER,MRC,TOXICOL UNIT,LEICESTER LE1 9HN,LEICS,ENGLAND

来源：

BIOMEDICAL CHROMATOGRAPHY | 1995年 / 9卷 / 03期

关键词：

D O I：

10.1002/bmc.1130090302

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Porphyrin metabolisms in human porphyria cutanea tarda (PCT) and in rats treated with hexachlorobenzene (HCB) have been studied in detail by high performance thin layer chromatography (HPTLC), high performance liquid chromatography (HPLC) and Liquid secondary ion mass spectrometry (LSIMS), The analyses of porphyrin metabolites in the urine, faeces and liver biopsies of patients with PCT have shown that apart from uroporphyrin I and III and their expected decarboxylation intermediates and products, a complex mixture of many other porphyrins are present. The new porphyrins identified are: meso-hydroxyuroporphyrin III, beta-hydroxypropionic acid uroporphyrin III, hydroxyacetic acid uroporphyrin III, peroxyacetic acid uroporphyrin III, beta-hydroxypropionic acid heptacarboxylic acid porphyrin III, hydroxyacetic acid heptacarboxylic porphyrin III and peroxyacetic acid pentacarboxylic porphyrin III.

引用

页码：113 / 122

页数：10

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