EFFICACY OF ENGINEERING CONTROLS IN REDUCING OCCUPATIONAL EXPOSURE TO AEROSOLIZED PENTAMIDINE

被引：7

作者：

MCDIARMID, MA ^{[1
]}

SCHAEFER, J ^{[1
]}

RICHARD, CL ^{[1
]}

CHAISSON, RE ^{[1
]}

TEPPER, BS ^{[1
]}

机构：

[1] JOHNS HOPKINS MED INST,BALTIMORE,MD 21205

来源：

CHEST | 1992年 / 102卷 / 06期

关键词：

D O I：

10.1378/chest.102.6.1764

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Aerosolized pentamidine administration may pose potential risks to health care workers exposed to fugitive drug and to infectious respiratory pathogens (eg, tuberculosis) generated by pentamidine-induced cough. Classic infection control methods may be applied to this problem, although the effectiveness of these measures in mitigating environmental pentamidine exposure is unknown. Lack of data fully characterizing pentamidine's mechanism of action or potential mutagenicity, carcinogenicity, or teratogenicity raises concern and suggests worker exposure and environmental contamination be minimized. We report herein on the efficacy of an aerosol containment hood in containing fugitive pentamidine aerosol during administration.

引用

页码：1764 / 1766

页数：3

共 13 条

[1]

CHAISSON RE, IN PRESS RESPIR CARE

[2]

DEREAMER R, 1980, FUNDAMENTALS IND HYG

[3]

MCDIARMID MA, 1989, LANCET, V1, P863

[4] SELECTIVE DELIVERY OF PENTAMIDINE TO THE LUNG BY AEROSOL [J].

MONTGOMERY, AB ;

DEBS, RJ ;

LUCE, JM ;

CORKERY, KJ ;

TURNER, J ;

BRUNETTE, EN ;

LIN, ET ;

HOPEWELL, PC .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 137 (02) :477-478

[5]

SMALDONE GC, 1991, NEW ENGL J MED, V325, P891

[6] INVESTIGATIONS ON MUTAGENICITY AND GENOTOXICITY OF PENTAMIDINE AND SOME RELATED TRYPANOCIDAL DIAMIDINES [J].

STAUFFERT, I ;

PAULINI, H ;

STEINMANN, U ;

SIPPEL, H ;

ESTLER, CJ .

MUTATION RESEARCH, 1990, 245 (02) :93-98

[7]

Waalkes T P, 1976, Natl Cancer Inst Monogr, V43, P171

[8]

WARING MJ, 1965, MOL PHARMACOL, V1, P1

[9] EFFECTS OF TRYPANOCIDES ON THE FINE-STRUCTURE OF TARGET ORGANISMS [J].

WILLIAMSON, J .

PHARMACOLOGY & THERAPEUTICS, 1979, 7 (03) :445-512

[10]

1990, MMWR, V39, P17

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