ASSIGNMENT OF THE HUMAN GENE FOR THE WATER CHANNEL OF RENAL COLLECTING DUCT AQUAPORIN-2 (AQP2) TO CHROMOSOME-12 REGION Q12-]Q13

被引：33

作者：

DEEN, PMT

WEGHUIS, DO

SINKE, RJ

VANKESSEL, AG

WIERINGA, B

VANOS, CH

机构：

[1] UNIV NIJMEGEN,DEPT HUMAN GENET,NIJMEGEN,NETHERLANDS

[2] UNIV NIJMEGEN,DEPT CELLULAR BIOL,NIJMEGEN,NETHERLANDS

来源：

CYTOGENETICS AND CELL GENETICS | 1994年 / 66卷 / 04期

关键词：

D O I：

10.1159/000133707

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The chromosomal localization of the gene encoding Aquaporin 2 (previously called WCH-CD), which acts as a water channel in the collecting tubules of the kidney, was determined. Southern blot hybridizations of chromosomal DNA from a panel of 25 different human-rodent hybrid cell lines assigned AQP2 to the q-arm of human chromosome 12. Additionally, in situ hybridization on R-banded metaphase chromosomes localized AQP2 to the q12-->q13 region of this chromosome.

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页码：260 / 262

页数：3

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