ACUTE HEPATITIS INDUCED BY HMG-COA REDUCTASE INHIBITOR, LOVASTATIN

被引:28
作者
GRIMBERT, S
PESSAYRE, D
DEGOTT, C
BENHAMOU, JP
机构
[1] HOP BEAUJON,SERV HEPATOL,INSERM,U24,UNITE RECH PHYSIOPATHOL HEPAT,F-92118 CLICHY,FRANCE
[2] HOP BEAUJON,SERV ANAT & CYTOL PATHOL,F-92118 CLICHY,FRANCE
关键词
DRUG-INDUCED HEPATITIS; LOVASTATIN;
D O I
10.1007/BF02088142
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The HMG-CoA reductase inhibitor, lovastatin, is known to induce asymptomatic liver dysfunction in a few patients. We report the case of an adult who suffered from clinical hepatitis three months after the onset of lovastatin administration. Manifestations included asthenia, jaundice, and increased aminotransferase and alkaline phosphatase activities. Histologic examination showed centrilobular necrosis, centrilobular cholestasis, and infiltrates with mononuclear and polymorphonuclear cells, including eosinophils. Withdrawal of lovastatin was followed by complete normalization of liver tests within two months. © 1994 Plenum Publishing Corporation.
引用
收藏
页码:2032 / 2033
页数:2
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