STUDIES ON DIFFERENTIATION-INDUCING ACTIVITIES OF TRITERPENES

被引：48

作者：

UMEHARA, K

TAKAGI, R

KUROYANAGI, M

UENO, A

TAKI, T

CHEN, YJ

机构：

[1] TOKYO MED & DENT UNIV, SCH MED, BUNKYO KU, TOKYO 113, JAPAN

[2] SHENYANG COLL PHARM, DEPT PHYTOCHEM, SHENYANG, PEOPLES R CHINA

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 02期

关键词：

CLOVE; TRITERPENE; DIFFERENTIATION-INDUCING ACTIVITY; PHAGOCYTOSIS; MACROPHAGE; M1; CELL; HL-60;

D O I：

10.1248/cpb.40.401

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Differentiation-inducing activity of over 180 extracts of crude drugs and plants was tested using mouse myeloid leukemia cell line (M1). The methanol extracts of clove (Syzygium aromaticum MERRILL et PERRY, Myrtaceae) showed remarkable induction of differentiation of M1 cells into macrophage-like cells. From the extract, oleanolic acid (1) and crategolic acid (2) were isolated as the active components. We also tested other triterpenes, such as oleananes, ursanes and dammaranes, to investigate the structure-activity relationship. Some triterpene aglycones showed differentiation-inducing activity, but triterpene glycosides showed little activity. Furthermore, the differentiation-inducing activity of these triterpene compounds was tested against human acute promyelocytic leukemia cell line (HL-60).

引用

页码：401 / 405

页数：5