NEUROPEPTIDES IN THE CEREBRAL-CIRCULATION - RELEVANCE TO HEADACHE

被引：95

作者：

EDVINSSON, L ^{[1
]}

GOADSBY, PJ ^{[1
]}

机构：

[1] NEUROL INST, LONDON, ENGLAND

来源：

CEPHALALGIA | 1995年 / 15卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1046/j.1468-2982.1995.1504272.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The article briefly describes the innervation of the human cerebral circulation by nerve fibers containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP). The neuropeptides in human cerebral arteries were characterized by radioimmunoassay in combination with HPLC. These neuropeptides mediate contraction (NPY) and dilatation (VIP, SP, CGRP). In conjunction with spontaneous attacks of migraine or cluster headache, release of CGRP is seen. With the associated symptoms of nasal congestion and rhinorrhea, VIP is released. Successful treatment may abort the peptide release in parallel with disappearance of headache.

引用

收藏

页码：272 / 276

页数：5

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