STRUCTURE OF INFLUENZA HEMAGGLUTININ AT THE PH OF MEMBRANE-FUSION

被引：1373

作者：

BULLOUGH, PA

HUGHSON, FM

SKEHEL, JJ

WILEY, DC

机构：

[1] HARVARD UNIV,DEPT BIOCHEM & MOLEC BIOL,CAMBRIDGE,MA 02138

[2] HARVARD UNIV,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02138

[3] NATL INST MED RES,LONDON NW7 1AA,ENGLAND

来源：

NATURE | 1994年 / 371卷 / 6492期

关键词：

D O I：

10.1038/371037a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 Angstrom to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.

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页码：37 / 43

页数：7

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[11] FUSION MUTANTS OF THE INFLUENZA-VIRUS HEMAGGLUTININ GLYCOPROTEIN [J].

DANIELS, RS ;

DOWNIE, JC ;

HAY, AJ ;

KNOSSOW, M ;

SKEHEL, JJ ;

WANG, ML ;

WILEY, DC .

CELL, 1985, 40 (02) :431-439

[12] THE RECEPTOR-BINDING AND MEMBRANE-FUSION PROPERTIES OF INFLUENZA-VIRUS VARIANTS SELECTED USING ANTI-HEMAGGLUTININ MONOCLONAL-ANTIBODIES [J].

DANIELS, RS ;

JEFFRIES, S ;

YATES, P ;

SCHILD, GC ;

ROGERS, GN ;

PAULSON, JC ;

WHARTON, SA ;

DOUGLAS, AR ;

SKEHEL, JJ ;

WILEY, DC .

EMBO JOURNAL, 1987, 6 (05) :1459-1465

[13]

DANIELS RS, 1985, ORIGIN PANDEMIC INFL, P8

[14]

DANIELS RS, 1985, ORIGIN PANDEMIC INFL, P1

[15]

DOMS RW, 1985, J BIOL CHEM, V260, P2973

[16] FUSION OF INFLUENZA HEMAGGLUTININ-EXPRESSING FIBROBLASTS WITH GLYCOPHORIN-BEARING LIPOSOMES - ROLE OF HEMAGGLUTININ SURFACE-DENSITY [J].

ELLENS, H ;

BENTZ, J ;

MASON, D ;

ZHANG, F ;

WHITE, JM .

BIOCHEMISTRY, 1990, 29 (41) :9697-9707

[17] STUDIES ON THE MECHANISM OF MEMBRANE-FUSION - SITE-SPECIFIC MUTAGENESIS OF THE HEMAGGLUTININ OF INFLUENZA-VIRUS [J].

GETHING, MJ ;

DOMS, RW ;

YORK, D ;

WHITE, J .

JOURNAL OF CELL BIOLOGY, 1986, 102 (01) :11-23

[18] INTRODUCTION OF INTERSUBUNIT DISULFIDE BONDS IN THE MEMBRANE-DISTAL REGION OF THE INFLUENZA HEMAGGLUTININ ABOLISHES MEMBRANE-FUSION ACTIVITY [J].

GODLEY, L ;

PFEIFER, J ;

STEINHAUER, D ;

ELY, B ;

SHAW, G ;

KAUFMANN, R ;

SUCHANEK, E ;

PABO, C ;

SKEHEL, JJ ;

WILEY, DC ;

WHARTON, S .

CELL, 1992, 68 (04) :635-645

[19] SERPINS - THE UNCUT VERSION [J].

GOLDSMITH, EJ ;

MOTTONEN, J .

STRUCTURE, 1994, 2 (04) :241-244

[20] PREPARATION OF INFLUENZA-VIRUS SUBVIRAL PARTICLES LACKING THE HA1 SUBUNIT OF HEMAGGLUTININ - UNMASKING OF CROSS-REACTIVE HA2 DETERMINANTS [J].

GRAVES, PN ;

SCHULMAN, JL ;

YOUNG, JF ;

PALESE, P .

VIROLOGY, 1983, 126 (01) :106-116

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