Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood

被引:71
作者
Catarino, Cristina [1 ,2 ]
Santos-Silva, Alice [1 ,2 ]
Belo, Luis [1 ,2 ]
Rocha-Pereira, Petronila [2 ,3 ]
Rocha, Susana [1 ,2 ]
Patricio, Belmiro [4 ,5 ]
Quintanilha, Alexandre [2 ,6 ]
Rebelo, Irene [1 ,2 ]
机构
[1] Faculdade Farm acia Univ Porto FFUP, Serv Bioquim, P-4050313 Oporto, Portugal
[2] Univ Porto, Inst Biol Mol Celular IBMC, P-4150180 Oporto, Portugal
[3] Univ Beira Interior, Centro Investigacao Cencias Saude CICS, 6201506 Covilha, Portugal
[4] Hosp Sao Joao, Serv Obstetr Ginecologia, P-4200319 Oporto, Portugal
[5] Univ Porto, Facul Med, P-4200319 Oporto, Portugal
[6] Univ Porto, Inst Cienc Biomed Abel Salazar ICBAS, P-4050313 Oporto, Portugal
关键词
D O I
10.1155/2012/684384
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Preeclampsia (PE) is one of the main causes of maternal and fetal mortality and morbidity. PE is associated with an inflammatory state and with oxidative stress, in maternal circulation. Our aim was to evaluate and compare the levels of oxidative stress and inflammatory markers in maternal and umbilical cord blood (UCB), in normal and PE pregnancies. We measured acute-phase proteins (CRP and alpha 1-antitrypsin), proinflammatory cytokines (IL-6 and TNF-alpha), leukocyte activation (elastase, lactoferrin, sL-selectin, sVCAM, sPECAM), total antioxidant status (TAS), thiobarbituric acid reactive substances (TBARS), and uric acid levels. We studied 42 healthy pregnant women, 46 PE women, and their neonates. The concentrations of IL-6, TNF-alpha, alpha 1-antitrypsin, CRP, sVCAM, uric acid, and TBARS were significantly higher, and sL-selectin was significantly lower in PE pregnant women as compared with normotensive pregnant women. In newborns uric acid, alpha 1-antitrypsin, and CRP values were significantly higher in PE; leukocyte count, sL-selectin, lactoferrin, and the ratio elastase/alpha 1-antitrypsin were significantly lower. Our data suggest that PE pregnancy is associated with an enhanced maternal inflammatory condition, which is reflected in fetal circulation. This enhanced inflammatory state seems to be related to endothelial dysfunction and increased cytokine synthesis, rather than with neutrophil activation.
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页数:10
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