ANTINOCICEPTIVE EFFECT OF TAURINE AND ITS INHIBITION BY NAXOLONE

被引：23

作者：

SERRANO, JS ^{[1
]}

SERRANO, MI ^{[1
]}

GUERRERO, MR ^{[1
]}

RUIZ, R ^{[1
]}

POLO, J ^{[1
]}

机构：

[1] UNIV SEVILLE,SCH MED,DEPT BIOSTAT,E-41009 SEVILLE,SPAIN

来源：

GENERAL PHARMACOLOGY | 1990年 / 21卷 / 03期

关键词：

D O I：

10.1016/0306-3623(90)90833-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. 1. We have tested the effect of taurine on nociceptive stimulation provoked by chemical agent (acetic acid) and by the hot-plate test. 2. 2. In the acetic acid test, taurine exerts an antinociceptive effect at every dose and time assayed. The observed effect was dose-related. 3. 3. Naxolone pretreatment antagonizes the antinociceptive effect of taurine in the acetic acid test. 4. 4. The results obtained in hot-plate test show that taurine did not significantly affect latency time for paw licking. © 1990.

引用

页码：333 / 336

页数：4

共 27 条

[11] DIFFERENTIAL SENSITIVITY OF MODELS OF ANTINOCICEPTION IN THE RAT, MOUSE AND GUINEA-PIG TO MU-OPIOID AND KAPPA-OPIOID RECEPTOR AGONISTS [J].

HAYES, AG ;

SHEEHAN, MJ ;

TYERS, MB .

BRITISH JOURNAL OF PHARMACOLOGY, 1987, 91 (04) :823-832

[12]

HENDERSHOT LC, 1959, J PHARMACOL EXP THER, V125, P237

[13] ANALGESIC PROPERTIES OF THE GABA-MINETIC THIP [J].

HILL, RC ;

MAURER, R ;

BUESCHER, HH ;

ROEMER, D .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1981, 69 (02) :221-224

[14]

Izumi K, 1980, Int J Neurol, V14, P253

[15]

KENDALL DA, 1982, J PHARMACOL EXP THER, V220, P482

[16]

KOSTER R, 1959, FED PROC, V18, P412

[17]

Kuriyama K, 1978, TAURINE NEUROLOGICAL, P201

[18]

OKAMOTO K, 1980, BRIT J PHARMACOL, V69, P467

[19] MINIREVIEW ON THE SPECIFICITY OF NALOXONE AS AN OPIATE ANTAGONIST [J].

SAWYNOK, J ;

PINSKY, C ;

LABELLA, FS .

LIFE SCIENCES, 1979, 25 (19) :1621-1631

[20] GABAERGIC MECHANISMS IN ANTINOCICEPTION [J].

SAWYNOK, J .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1984, 8 (4-6) :581-586

← 1 2 3 →