INVESTIGATION ON PROCESS PARAMETERS INVOLVED IN POLYLACTIDE-CO-GLYCOLIDE MICROSPHERES PREPARATION

被引：22

作者：

CONTI, B ^{[1
]}

GENTA, I ^{[1
]}

MODENA, T ^{[1
]}

PAVANETTO, F ^{[1
]}

机构：

[1] UNIV PAVIA,DIPARTIMENTO CHIM FARMACEUT,I-27100 PAVIA,ITALY

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1995年 / 21卷 / 05期

关键词：

D O I：

10.3109/03639049509048127

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Indomethacin loaded polylactide-co-glycolide (PLGA) microspheres were prepared by emulsification solvent evaporation. The preparation involves several process parameters that can affect the morphological characteristics, the ''in vitro'' and ''in vivo'' dissolution behaviour of microspheres. The evaluation of three process parameters, emulsification stirring rate, emulsifier concentration and dispersed phase to continuous phase ratio was carried out in order to correlate them to some microsphere properties. Results show that the variables evaluated affect mainly microspheres drug content and, at less extent, particle size.

引用

页码：615 / 622

页数：8

共 14 条

[1] ALBUMIN MICROSPHERES AND MICROCAPSULES - METHODOLOGY OF MANUFACTURING TECHNIQUES [J].