1-METHYL-4-PHENYLPYRIDINE IS NEUROTOXIC TO THE NIGROSTRIATAL DOPAMINE PATHWAY

被引:92
作者
BRADBURY, AJ
COSTALL, B
DOMENEY, AM
JENNER, P
KELLY, ME
MARSDEN, CD
NAYLOR, RJ
机构
[1] UNIV LONDON,DEPT NEUROL,MRC,MOVEMENT DISORDERS RES GRP,LONDON SE5 8AF,ENGLAND
[2] UNIV LONDON,INST PSYCHIAT,PARKINSONS DIS SOC,RES CTR,LONDON SE5 8AF,ENGLAND
[3] UNIV LONDON,KINGS COLL HOSP,SCH MED,LONDON SE5 8AF,ENGLAND
关键词
D O I
10.1038/319056a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:56 / 57
页数:2
相关论文
共 12 条
[1]  
BRADBURY A J, 1984, British Journal of Pharmacology, V83, p395P
[2]  
BRADBURY AJ, 1983, NEUROPHARMACOLOGY, V22, P1172
[3]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[4]  
CHIUEH CC, 1984, EUR J PHARMACOL, V100, P189, DOI 10.1016/0014-2999(84)90221-8
[5]  
DEGROOT J, 1959, VERH K NED AKAD WET, V52, P14
[6]  
DOMENEY AM, 1982, NEUROPHARMACOLOGY, V21, P327
[7]   EFFECTS OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE ON NEOSTRIATAL DOPAMINE IN MICE [J].
HEIKKILA, RE ;
CABBAT, FS ;
MANZINO, L ;
DUVOISIN, RC .
NEUROPHARMACOLOGY, 1984, 23 (06) :711-713
[8]  
HEIKKILA RE, 1984, NATURE, V311, P467, DOI 10.1038/311467a0
[9]  
LANGSTON JW, 1984, CAN J NEUROL SCI, V11, P160
[10]   PARGYLINE PREVENTS MPTP-INDUCED PARKINSONISM IN PRIMATES [J].
LANGSTON, JW ;
IRWIN, I ;
LANGSTON, EB ;
FORNO, LS .
SCIENCE, 1984, 225 (4669) :1480-1482