PARGYLINE PREVENTS MPTP-INDUCED PARKINSONISM IN PRIMATES

被引：575

作者：

LANGSTON, JW

IRWIN, I

LANGSTON, EB

FORNO, LS

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,STANFORD,CA 94305

[2] VET ADM MED CTR,DEPT PATHOL,PALO ALTO,CA 94304

来源：

SCIENCE | 1984年 / 225卷 / 4669期

关键词：

D O I：

10.1126/science.6332378

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：1480 / 1482

页数：3

共 12 条

[1]

BIRKMAYER W, 1983, PHARMACOPSYCHITARY, V19, P170

[2] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

BURNS, RS ;

CHIUEH, CC ;

MARKEY, SP ;

EBERT, MH ;

JACOBOWITZ, DM ;

KOPIN, IJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550

[3] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].

CHIBA, K ;

TREVOR, A ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578

[4]

CHIBA K, 1984, BIOCH BIOPHYS RES CO, V120, P2

[5]

FORNO LS, 1982, MOVEMENT DISORD, P25

[6]

HEIKKILA RE, NATURE LONDON

[7]

LANGSTON JW, 1984, CAN J NEUROL SCI, V11, P160

[8] CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS [J].

LANGSTON, JW ;

BALLARD, P ;

TETRUD, JW ;

IRWIN, I .

SCIENCE, 1983, 219 (4587) :979-980

[9] 1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) - IDENTIFICATION OF A METABOLITE OF MPTP, A TOXIN SELECTIVE TO THE SUBSTANTIA NIGRA [J].

LANGSTON, JW ;

IRWIN, I ;

LANGSTON, EB ;

FORNO, LS .

NEUROSCIENCE LETTERS, 1984, 48 (01) :87-92

[10]

LANGSTON JW, 1984, BRAIN RES, V292, P390

← 1 2 →