A NETWORK MODEL OF CATECHOLAMINE EFFECTS - GAIN, SIGNAL-TO-NOISE RATIO, AND BEHAVIOR

被引：531

作者：

SERVANSCHREIBER, D

PRINTZ, H

COHEN, JD

机构：

[1] UNIV PITTSBURGH,SCH MED,DEPT PSYCHIAT,PITTSBURGH,PA 15213

[2] DIGITAL EQUIPMENT CORP,PARIS RES LAB,F-92563 RUEIL MALMAISON,FRANCE

[3] CARNEGIE MELLON UNIV,DEPT PSYCHOL,PITTSBURGH,PA 15213

[4] STANFORD UNIV,MED CTR,SCH MED,DEPT PSYCHIAT & BEHAV SCI,STANFORD,CA 94305

来源：

SCIENCE | 1990年 / 249卷 / 4971期

关键词：

D O I：

10.1126/science.2392679

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

At the level of individual neurons, catecholamine release increases the responsivity of cells to excitatory and inhibitory inputs. A model ofcatecholamine effects in a network of neural-like elements is presented, which shows that (i) changes in the responsivity of individual elements do not affect their ability to detect a signal and ignore noise but (ii) the same changes in cell responsivity in a network of such elements do improve the signal detection performance of the network as a whole. The second result is used in a computer simulation based on principles of parallel distributed processing to account for the effect of central nervous system stimulants on the signal detection performance of human subjects.

引用

页码：892 / 895

页数：4

共 32 条

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