STEREOISOMERIC [1,2-BIS(3-HYDROXYPHENYL)ETHYLENEDIAMINE]PLATINUM(II) COMPLEXES .3. EVALUATION OF THE MAMMARY-TUMOR INHIBITING PROPERTIES

被引：10

作者：

SCHERTL, S ^{[1
]}

GUST, R ^{[1
]}

MULLER, R ^{[1
]}

SPRUSS, T ^{[1
]}

SCHONENBERGER, H ^{[1
]}

机构：

[1] UNIV REGENSBURG,INST PHARM,LEHRSTUHL PHARMAZEUT CHEM 2,SONDERFORSCH BEREICH 234,UNIV STR 31,W-8400 REGENSBURG,GERMANY

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 02期

关键词：

D O I：

10.1002/ardp.19923250211

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes produce a strong configuration-dependent inhibition of the hormone sensitive MXT-mammary carcinoma of the mouse. Besides an interference in the DNA synthesis in analogy to cisplatin an estrogen level lowering effect is supposed to be the mode of action. The new complexes show also a significant activity on the hormone-independent MXT-mammary carcinoma of the mouse.

引用

页码：113 / 118

页数：6

共 17 条

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[9] TUMOR-INHIBITING [1,2-BIS(FLUOROPHENYL)ETHYLENEDIAMINE]PLATINUM(II) COMPLEXES .3. EVALUATION OF THE MAMMARY-TUMOR INHIBITING PROPERTIES
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