GLUCOSE-METABOLISM IN THE BRAIN OF PATIENTS WITH ESSENTIAL TREMOR

被引：116

作者：

HALLETT, M

DUBINSKY, RM

机构：

[1] Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1993年 / 114卷 / 01期

关键词：

ESSENTIAL TREMOR; POSITRON EMISSION TOMOGRAPHY; GLUCOSE METABOLISM; CEREBELLUM; INFERIOR OLIVARY NUCLEUS; THALAMUS;

D O I：

10.1016/0022-510X(93)90047-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Using positron emission tomography with [F-18]fluoro-2-deoxyglucose, we determined the regional cerebral metabolic rate of glucose utilization at rest in 8 medication-free patients with essential tremor and in 10 normal subjects. Taking the metabolic values of regions of interest as ratios to the mean hemispheric metabolism, the patients showed significant glucose hypermetabolism of the medulla and thalami, but not of the cerebellar cortex. This study lends support to earlier suggestions that circuits involving the inferior olivary nuclei in the medulla and the thalmus are involved in the generation of essential tremor.

引用

页码：45 / 48

页数：4

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